Saka only played 24 minutes in the match before being replaced by Leandro Trossard. Having to move around on crutches after the match, it was clear that the Arsenal star had suffered a serious injury.
Arsenal manager Mikel Arteta said he was "quite worried" about Saka's injury, as he is a very important player for the Emirates Stadium team.
"We are quite worried about Saka's injury. He has a hamstring injury and cannot continue. He will have to undergo further tests, but we are hardly worried about his condition," said Areteta.
Saka is currently Arsenal's best attacking player. After 24 appearances since the beginning of the season, he has scored 9 goals and had 13 assists. In the Premier League, he has scored 5 goals and had 10 assists after 16 appearances.
Saka's excellent form has helped Arsenal to third place in the domestic league, competing with Liverpool and Chelsea for the championship. In the Champions League, the Gunners also have many opportunities to continue.
Saka's injury comes at a time when Arsenal are entering a fiercely competitive period in the Premier League, with a series of matches over Christmas and New Year.
The London team will not have many options to replace Saka, because Raheem Sterling recently suffered an injury during training, forcing him to completely leave the squad to face Palace.