In the first leg of the quarter-final, goalkeeper Andre Onana made mistakes in Man United's two goals conceded, helping Lyon equalize 2-2 in France.
The spirit of coach Ruben Amorim and his team continued to be affected with a heavy 1-4 away defeat to Newcastle in the Premier League at the weekend. It was also their 14th defeat of the season, and will certainly end the season with the lowest total points in the Premier League era.
The goal of winning tickets for the European Cup through the Premier League has gradually become impossible as the Reds have been 10 to 10 points behind the Reds. Recognizing the Europa League is the only end for the season, Man United has the pressure to win Lyon.
On the other side, the French representative still holds the 4th place in the Ligue 1 rankings, but has narrowed the gap to one point compared to Marseille in the third place - meaning a ticket to the Champions League next season.
Lyon have now won 7 of their last 9 matches in all competitions since the beginning of March, scoring 24 goals. They travel to Old Trafford with an unbeaten record in their last 12 away games in the Europa League (9 wins, 3 draws).
However, Lyon lost both times to Old Trafford before that, with the score 1-2 in November 2004 and 0-1 in March 2008. They have also never qualified directly for Europe when they drew in the first leg at home in the previous 9 times.
This is a match of great significance for Man United and the home team will focus all their efforts to win.
Score prediction: Man United 3-2 Lyon
