Arsenal are on a roll after beating PSG 2-0 in the UEFA Champions League in midweek and also beating Leicester 4-2 in the Premier League last weekend.
Manager Mikel Arteta is "super excited" and his next target is to chase the top spot in the Premier League table in a race with Liverpool and Manchester City.
The possibility of the Gunners falling behind seems very slim, as they have not lost at home to Southampton since 1987 (W19, D9).
A 40-game unbeaten run against promoted sides at home (W35 D5) means Gunners fans are confident of three points.
That confidence comes from a defensive foundation, with no team in Europe's top five leagues able to match Arsenal's 17 clean sheets in all competitions in 2024.
Southampton head north after a 3-1 defeat to Bournemouth to make their worst start in six top-flight games (D1 L5).
Manager Russell Martin says he "doesn't recognise" his team and is facing calls for changes with only Wolves below them in the Premier League table.
Having seen their side lose six consecutive away games – conceding at least three times in five of those – Saints fans are not overly optimistic heading into London, despite their most recent away point in the Premier League coming against Arsenal (a 3-3 draw in April 2023).
Link to watch Arsenal vs Southampton live:
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