A slow-moving weather pattern could produce the heaviest snowfall in decades. The Storm Forecast Center has issued a level 3 out of 5 severe weather levels.
CNN meteorologist Tyler Mauldin said that areas of Wyoming state - including Cheyenne and Nebraska - are under snowstorm warnings, while winter storm warnings and announcements are in effect for other areas in the region.
Weather forecast shows that heavy rains of about 100mm across the Midwest will occur over 72 hours before slowly moving to the East Coast next week, bringing wet days. As it gradually subsided in areas affected by snow on 15 March, another weather pattern was ready to replace it and continue to bring cold rain.
Mr. Mauldin said that snow in central areas of the US increased on March 13 and is likely to peak on March 14. Denver could see up to 60cm of snow, while the Front range and Foothills could see up to 1.2 meters of snow. The highest elevations in southeastern Wyoming could see more than 1.2 meters of snow.
The area is no stranger to snowfall in March. In fact, March is actually the heaviest month of the year for parts of Colorado and Wyoming.
On March 14, severe storms will move eastward into Arkansas, Mississippi, Louisiana and Tennessee.
Meanwhile, a tornado warning has been issued for Texas. There have been reports of tractor-trailers overturned on Interstate 27 south of Amarillo, Texas, due to a tornado on the afternoon of March 13. The Amarillo meteorological agency confirmed an "extremely dangerous" tornado was detected just west of Palo Duro Canyon. Some tornado warnings have come into effect in the area.
Police chief Christopher Forbis said on Facebook that there was a report on a baseball-sized football equivalent of a football, where two tornadoes were reported at the same time and many power lines were broken.
CNN meteorologist Gene Norman said the storms could produce golf ball-sized or larger hail and strong gusts of wind at a speed of 112km/h.
Flood warnings are also a major concern in the Middle West. Heavy rain is forecast to bring rivers to dangerous levels.
Flooding is also a threat on March 14, especially in parts of Missouri, Kansas and Illinois.
Other states such as Arkansas, Oklahoma, Kentucky and Indiana could also see flooding, especially if multiple storms pass through the same location.
Total widespread rainfall as of March 14 is expected to be between 50-100mm, but some isolated areas may exceed 150mm.