Man United have appointed assistant Ruud van Nistelrooy as interim manager, while negotiations with Sporting Lisbon to bring Ruben Amorim into the hot seat are ongoing.
Below are the 5 most notable points in the Man United - Leicester City match.
Welcome Van Nistelrooy
Van Nistelrooy is seen as a smart addition to Ten Hag's backroom staff and has been praised by the players, who have enjoyed working with a former United great. He is a trusted man in the interim role and will receive a warm welcome at Old Trafford.
Van Nistelrooy is also a favourite with United players and fans and is expected to pick a strong team to beat Leicester City, in what could be his only game in charge of the club. If the deal goes through, Ruben Amorim could become United's new manager ahead of Sunday's game against Chelsea.
Amass debut for first team?
Promising youngster Harry Amass has impressed on the pre-season tour of the United States and travelled to Wembley for the Community Shield, but he is yet to make a first-team appearance, despite Luke Shaw and Tyrell Malacia continuing to miss out through injury.
Erik Ten Hag did not believe Amass was physically ready, so he did not start him in the 7-0 win over Barnsley in the Carabao Cup.
However, Van Nistelrooy is likely to give Amass a chance to play at left-back, marking his first-team debut. With his poor form against West Ham, Diogo Dalot may have to drop to the bench, making way for Noussair Mazraoui to play at right-back.
Is it Ugarte's time to shine?
Manuel Ugarte was the standout player in Man United's 1-1 draw with Fenerbahce in the Europa League, but he was then left out of the starting line-up against West Ham last weekend.
The 23-year-old is expected to return to the starting line-up against Leicester, which could be a crucial step towards Ugarte becoming a regular starter at United. Ugarte thrived at Sporting Lisbon under Ruben Amorim, so with Amorim almost certain to join United, Ugarte could be set for more regular game time.
Has Man United's form improved?
The trip to Old Trafford to face Leicester will be Man United's first game since Ten Hag was sacked and it will be interesting to see how the players react to his departure.
Several Man United players sent messages of thanks to Ten Hag on social media when his sacking was confirmed, but there will be some in the dressing room who are relieved.
There are many sources saying that many Man United players did not listen to Erik ten Hag, leading to Man United's poor results. Therefore, many fans will wait to see the reaction of the players, as well as the whole team after he was fired.
Scoring problem
Man United created enough chances in the first 45 minutes against West Ham to score 1, even 2-3 goals. However, their players were too unlucky, leading to mistakes and defeat in the second half.
The 1-2 defeat to West Ham was also the last straw that led to Ten Hag's dismissal. The match against Leicester City is an opportunity for Man United to correct the mistakes of the past week, especially in scoring.
The match between Man United and Leicester City will take place at 2:45 a.m. on October 31.