Here are some notable statistics about this match, according to Liverpool's homepage.
This will be the 213rd meeting between the two clubs in the English top flight, becoming the second most played match in the history of the top flight after Aston Villa's clash with Everton (215 games).
Liverpool have lost just one of their last 28 home games against Everton in all competitions (17 wins, 10 draws), and have won all four of their most recent matches.
The Merseyside derbies saw the most red cards in Premier League history with 25 red cards, more than any other match.
Liverpool have won all 4 matches since the beginning of the season, if they beat Everton, they will have won all 5 matches at the beginning of the season for the 3rd time after the 2018-19 and 2019-20 seasons.
Arne Slot's side will aim to keep three consecutive clean sheets in the competition for the first time since September 2024.
Since the start of last season, Liverpool have scored more goals in the last 10 minutes of the match than any other team in the Premier League with 19 goals.
Everton have won six of their last 11 away games in the Premier League (2 draws, 3 losses), as many as they have won in their previous 30 combined.
Mohamed Salah has scored eight goals against Everton for Liverpool in the Premier League. Only Steven Gerrard (9 goals) has a better record.
Salah now only needs to score two more goals to reach the 250-goal mark for the club in all competitions.
The last meeting, in April 2025, Liverpool won 1-0 at Anfield thanks to Diogo Jota's second-half goal - his last goal for the club.
Liverpool are unbeaten in their last 19 Premier League games at Anfield (15 wins, four draws).
Since the start of the 2023-2024 season, Liverpool have not lost any of their eight Premier League games starting at 6:30 p.m. (Vietnam time) on Saturday (6 wins, 2 draws).
In contrast, the Toffees (Everton's nickname) have failed to win in their last nine top-flight games at 6:30 p.m. on Saturday (4 draws, 5 losses).
Alisson Becker has kept seven clean sheets in 11 league appearances against Everton, with only two Liverpool goalkeepers having more, Ray Clemence (14 games) and Pepe Queen (8 games).
Only the encounters between Chelsea and Man United (27) have had more draws than the clashes between Liverpool and Everton (26) in the Premier League.
Rio Ngumoha could become the youngest player ever to feature in the Merseyside derby if he plays against Everton (at the age of 17 years and 22 days).
The youngest player to score for Liverpool in the Merseyside derby was Robbie Fowler, then aged just 18 years and 338 days when Liverpool won 2-1 at Anfield in 1994.
Nearly 43 per cent of Liverpool's goals this season have been scored after the 82nd minute.