At the end of the first half, Bruno felt uncomfortable in his right leg, but still suppressed the pain of playing until the final whistle.
Lisandro Martinez was Bruno's replacement after the half-time break, while Fernandes had to watch the second half of the match from the bench.
After the match, coach Ruben Amorim was asked about the health of the Portuguese player and updated information about this issue, in the context that Man United will have a fairly tight schedule in the coming time.
"I think Bruno has a soft tissue injury, so it will take some time. I think he will miss a few games, I'm not sure so let's see. He is always fit so he can recover quite quickly but I don't know how long he will be out," Amorim said.
Since the beginning of the tournament, Bruno Fernandes has been one of Man United's best players. He has played 17 Premier League games, scoring 5 goals and providing 7 assists.
The absence of Fernandes will be a big blow to Amorim, who is currently without Bryan Mbeumo, Amad Diallo and Noussair Mazraoui during his time participating in the African Football Cup.
The two central defenders Matthijs de Ligt and Harry Maguire are also injured and have no return date yet. Meanwhile, Kobbie Mainoo was also withdrawn from the Villa squad at the last minute after having calf problems during training.
Due to the inability of many key players to play, coach Ruben Amorim was forced to give the first-team debut opportunity to two 18-year-old new players, Jack Fletcher and Shea Lacey at Villa Park.
Man United's next match will be against Newcastle at Old Trafford on Boxing Day, and if Fernandes is absent in this match, it will be only the third time he has been sidelined through injury or illness since moving from Sporting CP in January 2020.
The Portuguese midfielder missed one game due to a flu in March 2022 and two games due to a knee injury in May 2024.
However, in the match against Newcastle, Man United will have the return of midfielder Casemiro after suspension.