The Brazilian midfielder received a yellow card in the 4-4 draw with Bournemouth in the previous round, which means he will be suspended for one match.
Man United will also be without Noussair Mazraoui, Amad and Bryan Mbeumo, who are in Morocco for the African Cup.
In addition, coach Ruben Amorim also said Matthijs de Ligt and Harry Maguire will not be on the list due to injury. The centre-back is continuing his recovery from injury at Carrington.
"I think everyone is fine. The players were ready for the match. Apart from the players that everyone knows, I think no player has to miss the game due to injury, Amorim said.
Amorim also commented that Kobbie Mainoo "played very well" coming off the bench against Bournemouth and clearly this midfielder is an option to be in the starting lineup.
Meanwhile, coach Unai Emery hopes goalkeeper Emiliano Martinez can return to the goal after being absent in wins against Basel and West Ham United.
"Emiliano are recovering well. He is training separately and feels much better, much better. we will decide whether he can play on Sunday, Unai Emery said.
On the Aston Villa side, Tyrone Mings, Pau Torres and Ross Barkley are unable to play, while Liverpool's loan player, Harvey Elliott, is sick.
Winger Jadon Sancho is not eligible to participate because he is on loan to Man United.
"Tyrone is still injured. He is recovering well. Maybe, in a few weeks, he will join the team again. Pau Torres is no exception. About a week or two, thats great. Ross Barkley is still injured, longer than the other two players.
Elliott was sick today. He didn't train today, nor yesterday," Emery added.
Former Man United player Victor Lindelof has won a place in the starting lineup and will likely face his former club on Sunday.
The Aston Villa vs Man United match will take place at 11:30 p.m. on December 21.
