Arsenal moved up to seventh in the table after a 5-1 win over Sporting in their previous game. Mikel Arteta's side beat both Shakhtar Donetsk and PSG to take 10 points.
Arsenal have struggled to keep clean sheets at the Emirates in the past, but with key players returning from injury, the Gunners have been better defensively, conceding just twice in their last six games.
They are yet to lose at home in any competition this season and their form in north London has been solid with seven wins in their last eight games.
On the other side, Monaco also has 10 points after 5 matches in the Champions League this season, ranked right behind Arsenal due to poor goal difference.
Coach Adi Hutter's team are currently five points behind leaders PSG in Ligue 1, and level on points with second-placed Marseille. They have proven themselves to be a real contender in France's top flight.
But it is very difficult to beat Arsenal at this time. The last time Monaco won away in the Champions League was in the 2014-2015 season. The gap in the rankings is very close, so losing points will significantly affect the rankings of the teams.
Expected lineup
Arsenal: Raya; Timber, Saliba, Kiwior, Tierney; Odegaard, Rice, Merino; Saka, Havertz, Martinelli
Monaco: Majecki; Vanderson, Salisu, Kehrer, Henrique; Zakaria, Camara; Akliouche, Ben Seghir, Golovin; Embolo