This is the 10th time in the last 11 seasons in the European Cup that Liverpool have faced Spanish teams and the sixth consecutive Champions League season they have met a team from Madrid.
Liverpool have won four, drawn one and lost one of their last six against Spanish opponents at Anfield.
Liverpool are only two goals away from reaching 500 goals in the European Cup/Champions League.
Mohamed Salah is about to have his 200th match at Anfield for the Reds ( Liverpool's call-up). He now has 137 home goals for the club.
Salah needs two more goals to become the first African player to score 50 goals in the UEFA Champions League.
Dominik Szoboszlai and Virgil van Dijk have played every minute of Liverpool in this season's Champions League campaign.
Conor Bradley will be absent from the home game against PSV Eindhoven later this month if he receives a red card against Real Madrid.
Ibrahima Konate could play his 50th career in the UEFA club competition.
The Anfield side have had seven different goalscorers in Europe this season, the most in three games since the 1981-1982 season in the European Cup.
No of Liverpool's last 29 UEFA group stage games have ended in a draw, since a 1-1 draw with Midtjylland in December 2020.
Real Madrid have won three of their three Champions League games this season, beating Marseille 2-1 at home, 5-0 at Kairat Almaty and 1-0 at Santiago Bernabeu over Juventus.
Kylian Mbappe is currently the top scorer in the Champions League with five goals, along with Bayern Munich's Harry Kane.
Xabi Alonso will be the third head coach to lead two different sides to Anfield in Europe for two consecutive seasons. Previously, there were the cases of Ronald Koeman (Benfica in the 2005-2006, PSV Eindhoven in the 2006-2007) and Eric Gerets ( Galatasaray in the 2006 2007 and Marseille in the 2007-2008).
Real are playing in the Champions League for the 29th consecutive season, a record they shared with Barcelona, and have reached the semi-finals or even further in 12 of the last 15 seasons.
This is Real's 63rd meeting with an English club in the European Cup; so far, they have won 26, drawn 16 and lost 20.
Liverpool and Real are the only team to have faced each other in the three finals of this tournament in 1981, 2018 and 2022.
This will be Real Madrid vs Liverpool's 13th meeting, all of which will take place in the European Cup.
