According to the draw results, No. 1 seed Sinner will face a player who passed the qualifying round in the opening match. If he goes deep, the potential opponents of the Italian player may be Gabriel Diallo (3rd round), Tommy Paul (4th round) and Alex de Minaur in the quarterfinals. In the semi-finals, Sinner is likely to face one of the players such as Ben Shelton, Arthur Fils or Lorenzo Musetti.
Meanwhile, Zverev - the second seed and two-time Madrid Open champion will meet the winner in the match Mariano Navone and Nuno Borges in the opening round. Notable opponents on the German player's journey may include Ugo Humbert, Jakub Mensik and especially Daniil Medvedev in the quarterfinals. Currently, Medvedev is leading Zverev 14-8 in head-to-head record.
If he overcomes the challenges in the semi-finals against names like Felix Auger-Aliassime or defending champion Casper Ruud, Zverev is likely to rematch Sinner in the final.
Sinner is aiming for his fourth consecutive ATP Masters 1000 title this season after championships at Indian Wells, Miami and Monte Carlo. Meanwhile, Zverev needs to regain stability after stopping in the semi-finals of the Munich Open 2026.
According to the ATP ranking announced on April 20, Sinner continues to lead with 13,350 points, ranked above Alcaraz (12,960 points) and Zverev (5,255 points). The achievement at the Madrid Open 2026 will significantly affect the point gap between the leading group.
