Medical staff said that most of the dead were victims of a series of Israeli airstrikes on houses in the Jabalia area, northern Gaza.
The Israeli military then issued a new evacuation order for residents in several districts of Gaza City on May 14, forcing thousands of Palestinians to flee their homes.
According to a map published by the Israeli military, areas under evacuation warnings include some of the largest Shifa schools and hospitals in Gaza City.
Immediately after the evacuation order, Israeli aircraft carried out a number of airstrikes on targets inside Gaza city.
On May 13, the Israeli press quoted the country's security officials as saying that they believe that Hamas military leader Mohammad Sinwar and other senior officials were killed in an airstrike on the same day on what the Israeli military described as a command and control budge located under the European Hospital in Khan Younis city, south of Gaza.