If Arsenal win against Manchester City, they will widen the gap with their opponents to 8 points on the rankings. At that time, the right to decide will be in the hands of the "Gunners" regardless of Man City's result.
On the contrary, if they win all 3 points against Arsenal, Man City will take a long way to the 5th championship title in the last 6 Premier League seasons.
If it were a draw, the title race would become much more unpredictable as Man City were still 5 points behind Arsenal but played 2 less matches.
In the first leg at the Emirates, Man City won 3-1, Kevin De Bruyne, Jack Grealish and Erling Haaland were the players who scored for the defending champions.
In terms of personnel, coach Pep Guardiola has moved John Stones to the center when Man City had the ball and completely changed the lineup in the last few matches.
Nathan Ake is Man City's only absentee at the moment after having problems in the match against Bayern Munich.
The Spaniard has allowed many key players to rest in the semi-final against Sheffield in the FA Cup, so Man City will almost certainly have the strongest force.
On the other side of the front line, coach Mikel Arteta may abandon the 4-3-3 formation to move to a more defensive lineup.
Granit Xhaka is unlikely to play when recovering from injury and will have to undergo a fitness test. In the context of the Swiss player being unable to play, Fabio Vieira will play from the start.
In addition, William Saliba will continue to be absent due to a back injury. Takehiro Tomiyasu and Mohamed Elneny are also out for the rest of the season.