Dehydration reduces discharge capacity
Dehydration is a fairly common cause but is often underestimated. When the body is not provided with enough water, the kidney's filtration activity may be affected, making waste elimination ineffective.
In this case, uric acid easily accumulates in the blood instead of being eliminated through urine. This condition often occurs in hot weather days, after exertion, long travel, or when drinking insufficient water for a long time.
Metabolic stress causes temporary increase in uric acid
Major changes in lifestyle or health can cause the body to fall into a state of metabolic stress. At that time, the rate of tissue and energy breakdown increases, causing more purine to be broken down and leading to increased uric acid.
This condition can occur when exercising too much, suffering from a serious illness, infection, losing weight too quickly, fasting or skipping meals, as well as when under prolonged psychological pressure.
The body still produces uric acid itself
Uric acid does not only come from food. During natural metabolism, when old cells in the body are destroyed and regenerated, purines are also released and converted into uric acid.
If the body produces more of this substance than normal, blood uric acid levels can increase even if diet does not change. Conditions such as infection, inflammation, trauma, or when the body is under great physical pressure can also promote endogenous uric acid production.
Kidney function plays an important role
The kidney is the organ responsible for removing most uric acid from the body. About two-thirds of the daily uric acid is excreted through this organ.
When kidney function declines, even at a mild level, the ability to filter and excrete waste also decreases. This makes uric acid easily accumulate in the blood. In addition, metabolic syndrome or genetic factors can also cause the uric acid index to increase even when the diet is quite healthy.
Some medications can increase uric acid
Some medications can affect the kidney's uric acid excretion process. For example, diuretics commonly used for people with high blood pressure, some cardiovascular medications or chronic disease medications when used for a long time.
These drugs can reduce the ability to excrete uric acid, causing this substance to gradually accumulate in the body. If you suspect that the medication you are using affects your uric acid index, patients should consult a doctor for appropriate advice.
