Current cooking methods such as deep frying or grilling at high temperatures cause the proteins in food to change. These proteins are broken down into amino acids, then converted into purine nucleotides, and finally into uric acid.
On the other hand, protein is also broken down into a large amount of nitrogen, which the human body cannot use. This amount of nitrogen participates in the synthesis of purine.
Most exogenous purines are not absorbed by the body but are converted into uric acid. Therefore, uric acid in the body comes from exogenous purines, the main cause of which is protein.
Uric acid in the body is filtered through the glomerulus, then undergoes reabsorption, secretion and reabsorption in the renal tubules.
This system helps maintain normal uric acid levels in the blood. However, when there is a problem in the glomeruli or renal tubules, uric acid levels in the blood can increase.
Protein metabolites include not only nitrogen but also strongly acidic compounds such as phosphoric acid, pyruvate and ammonia. These substances, when accumulated for a long time, can cause damage to the glomerular membrane, reducing the filtration capacity of the glomerulus. At the same time, damage to the renal tubules can impair the ability to reabsorb or excrete uric acid, leading to high blood uric acid levels.
